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What is the most common cause of acute kidney injury?

The most common cause of acute kidney injury (AKI) is ischemia, which refers to reduced blood flow to the kidneys. Measures to correct underlying causes of acute kidney injury (AKI) should begin at the earliest indication of kidney dysfunction. Serum creatinine does not rise to abnormal levels until a large proportion of the renal mass is damaged, because the relationship between the glomerular filtration rate (GFR) and the serum creatinine level is not linear, especially early in the disease. Indeed, the rise of serum creatinine may not be evident before 50% of the GFR is lost.


It cannot be overstated that the current treatment for AKI is mainly supportive; no therapeutic modalities to date have shown efficacy in treating the condition. Therapeutic agents (eg, dopamine, nesiritide, fenoldopam, mannitol) are not indicated in the management of AKI and may be harmful to the patient.


Maintenance of volume homeostasis and correction of biochemical abnormalities remain the primary goals of treatment and may include the following measures:
Correction of fluid overload with furosemide
Correction of severe acidosis with bicarbonate administration, which can be important as a bridge to dialysis
Correction of hyperkalemia
Correction of hematologic abnormalities (eg, anaemia, uremic platelet dysfunction) with measures such as transfusions and administration of desmopressin or estrogens.
Volume overload:
The Swanand Kidney Clinic emphasizes the importance of early detection and treatment to prevent complications associated with fluid overload, ensuring better health


Causes of Volume Overload :
Volume overload can arise from several underlying conditions, including:
Heart Failure: Impaired heart function can lead to fluid retention, as the kidneys may not receive adequate blood flow to perform their filtering duties effectively.
Kidney Dysfunction: Conditions like chronic kidney disease or acute kidney injury can hinder the kidneys' ability to excrete excess fluid.

Cirrhosis: Liver disease can disrupt fluid balance, contributing to fluid accumulation in the body.

Hormonal Changes: Conditions that affect hormone levels, such as pregnancy, can also lead to fluid retention.




Hyperkalemia
At Swanand Kidney Clinic, we prioritize the management of hyperkalemia through comprehensive kidney care. Our team, led by Dr. Snehal Shankar Gaikwad, specializes in diagnosing and treating conditions related to kidney health. Hyperkalemia in patients with Acute kidney injury treatment can be life-threatening. Approaches to lowering serum potassium include the following:

Decreasing the intake of potassium in diet or tube feeds
Exchanging potassium across the gut lumen using potassium-binding resins
Promoting intracellular shifts in potassium with insulin, dextrose solutions, and beta-agonists
Instituting dialysis
Nephrotoxic agents:
Consultation
Nephrology consultation should be sought early in the course of AKI. A nephrologist can help to optimize management and avoid the preventable complications of AKI.



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